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The addition of Retatrutide, which improves insulin sensitivity through GLP-1 and GIP pathways, likely offsets any mild glucose-raising effect from Tesamorelin

The potential link between GLP-1 therapies and gout risk is gaining attention as clinicians look beyond glucose control to broader metabolic outcomes

Importantly, the association was more pronounced in patients with obesity/overweight, indicating a potential protective effect against CRC that may be partly driven by weight loss, as well as other mechanisms unrelated to weight loss